Several studies have explored interactions between LPL polymorphisms and macronutrient intake, providing mixed results.A study by Kim et al. (2013) in South Korea demonstrated that metabolic syndrome components were significantly modified by interactions between LPL polymorphisms (including rs320) and carbohydrate intake14.Similar lipid changes were noted by Faleti et al. (2023) in a study involving a Nigerian population, with the rs320 polymorphism demonstrating a strong connection to higher TG and TC levels15. The gene discussed is LPL; the disease is metabolic syndrome.