SLFN11 and chronic myelogenous leukemia, BCR-ABL1 positive: HAP1 is a near-haploid human cell line derived from the KBM-7 chronic myelogenous leukemia (CML) cell line that expresses SLFN11, and acquires resistance to perturbations that induce replication stress upon SLFN11 loss17,32,42.