KEGG and GO enrichment analyses indicated that the Piezo1/BHLHE40 signaling axis was primarily associated with endothelial inflammatory signaling pathways, including the TNF signaling pathway, IL-17 signaling pathway, and fluid shear stress and atherosclerosis (Fig. S3F, I), which are closely related to vascular homeostasis and endothelial dysfunction. The gene discussed is IL17A; the disease is endothelial dysfunction.