Using siRNA gene knockdown of NRF2 in RD and Rh41 OT resistant tumor cells, we showed that MDR1, MRP1, and BCRP were significantly reduced at both the mRNA and protein levels in all models tested following NRF2 knockdown (Fig. 5A, B and Supplementary Fig. 10A, B). The gene discussed is ABCC1; the disease is neoplasm.