Using siRNA gene knockdown of NRF2 in RD and Rh41 OT resistant tumor cells, we showed that MDR1, MRP1, and BCRP were significantly reduced at both the mRNA and protein levels in all models tested following NRF2 knockdown (Fig. 5A, B and Supplementary Fig. 10A, B). Here, NFE2L2 is linked to neoplasm.