SPHKAP and type 2 diabetes mellitus: Additionally, we found SPHKAP mRNA expression to be decreased in a published RNA-Seq database of islets from db/db versus WT mice (Supplementary Fig. 5b), and meta-analyses from four separate genome-wide association studies (GWAS) in humans uncovered genome-wide significant associations between SPHKAP gene variants, T2D risk, and high BMI36–39 (Supplementary Fig. 5c, d).