In addition to the role of OSM in STAT-5-driven leukemia, OSM deficiency in donor BM or the injection of Kmt2a::Mllt3+ BM into Osmr-deficient mice had no effect on median survival, WBC count, or lineage distribution compared with that in WT mice (Fig. 5f, g). The gene discussed is MLLT3; the disease is leukemia.