FLT3 and neoplasm: A link between oncogenic signaling and the tumor microenvironment (TME) has been demonstrated in several hematological malignancies.1–3 Aberrant activation of signaling pathways such as JAK–STAT, FLT3, and BCR::ABL1 not only drives uncontrolled cell proliferation but also remodels the surrounding stroma to create a supportive niche for malignant hematopoiesis.