We found that OSM overexpression profoundly reprogrammed BM stromal cells and induced the secretion of the cytokines IL-6 and MCP-1, which are linked to T-cell exhaustion and the induction and expansion of MDSCs.20,39,50–52 The connection between OSM and T-cell exhaustion has not been reported in the context of hematological malignancies. The gene discussed is OSM; the disease is hematologic disorder.