A study investigating the role of the anti-apoptotic protein Bcl-2-assocaited athanogene 3 (BAG3) in the heart revealed that in adult left ventricular cardiomyocytes, BAG3 modulates cardiomyocyte contraction and action potential duration by interacting with β1-AR and LTCC, thereby reducing the risk of arrhythmias [162]. Here, BAG3 is linked to cardiac arrhythmia.