Colorectal carcinoma MC38, lung carcinoma 3LL and pancreaticcarcinoma PAN02 cell lines were chosen as suitable models for thesestudies given their variable expression levels of DR5 (Figure A) and other extrinsic apoptoticproteins, including the key inhibitory protein FLIP (Figure B). Here, TNFRSF10B is linked to lung carcinoma.