TNFRSF10B and neoplasm: We compared the abilityof the nanoparticles to target murine DR5 and induce apoptotic celldeath in a panel of tumor cell lines, versus MD5–1 in nativebivalent format, and whether these effects could be further enhancedthrough encapsulating CPT to yield nanoparticles with dual functionality.Moreover, we also investigated the in vivo tolerabilityand efficacy of the nanoparticles in the syngeneic MC38 model of CRC.