C4B and Alzheimer disease: Additionally, comparison of the variants identified in our study revealed overlap with previously reported LOY-associated transcriptional effects (LATEs) genes: 18 UD-CH and 2 LD-CH genes had been reported to be dysregulated in myeloid cells of LOY subjects with AD (Dumanski et al, 2021; Jąkalski et al, 2025), whereas 51 UD-CH, 4 LD-CH, and 2 MD-CH genes corresponded to hypomethylated genes found in granulocytes and monocytes of AD-LOY patients (Jąkalski et al, 2025).