CD4 and tuberculosis: The three earlier trials tested SDI interventions in participants eligible for ART under then-current guidelines (eg, CD4 ≤350/500 cells/μL), using same-day diagnostics and same-day counselling.9 11 12 Rosen et al. (South Africa) introduced a simplified algorithm to screen-in participants eligible for SDI, by screening out participants with TB symptoms, ongoing TB treatment or other contraindications for SDI, eliminating the need for additional diagnostics or counselling.31