FGF1 and type 2 diabetes mellitus: To determine the time course of the transcriptional effect of FGF1 on MBH cell types in a mouse model of T2D, diabetic Lepob/ob mice received an icv injection of either recombinant human FGF1 (3 μg; FGF1-ob) or saline vehicle (Veh-ob), while wild-type C57BL/6 control mice received icv vehicle (Veh-WT).