SNCA and Lewy body dementia: The accumulation of misfolded and aggregated alpha-synuclein (αSyn) in the brain is a pathological hallmark of a group of neurodegenerative diseases collectively called synucleinopathies, which include Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) (1, 2, 3, 4, 5).