The accumulation of misfolded and aggregated alpha-synuclein (αSyn) in the brain is a pathological hallmark of a group of neurodegenerative diseases collectively called synucleinopathies, which include Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) (1, 2, 3, 4, 5). The gene discussed is SNCA; the disease is multiple system atrophy.