These functional abnormalities may have been related to the obstruction of Aβ (β-amyloid protein) and Tau protein propagation and abnormal aggregation in AD (Chételat et al., 2020, Nguyen et al., 2024, Pignataro and Middei, 2017, van der Kant et al., 2019, Vogel et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.