Of note, whereas MAS, HCS, WCS were each significantly correlated with age at cancer diagnosis (|Spearman's rho| > 0.60, p < 0.05), AMS was not (Spearman's rho = 0.25, p = 0.43), suggesting that the latter metrics is not a significant predictor of TP53 variant immunogenicity (Figure S2A). Here, TP53 is linked to cancer.