MAPRE1 and cancer: The EB1c region contains conserved EB1 homology (EBH) domain, which regulates +TIPs networks by recruiting a range of other +TIPs, such as cancer-related proteins APC and microtubule-actin cross-linking factor (MACF), through the interaction with the SxIP motifs (Gouveia and Akhmanova, 2010; Honnappa et al., 2009; Kumar and Wittmann, 2012).