In ourpatient cohort, creatinine clearance was above the upper referencelimit, suggesting a tendency toward hyperfiltration, a common findingin obesity. In contrast, serum creatinine,urea, urinary albumin, and protein excretion remained within the referenceranges, indicating no overt impairment of kidney function. The gene discussed is ALB; the disease is obesity due to melanocortin 4 receptor deficiency.