DM establishes a proinflammatory state marked by increased interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP), which acutely enhance endothelial permeability, promote leukocyte infiltration, and induce cardiomyocyte cytokine toxicity [12,13]. This evidence concerns the gene TNF and diabetes mellitus.