E2F1 and neoplasm: We further investigated contexts of these spMOCA’s hub genes, where we identified specific prognostic genes serves as hub genes in the same tumor type, for example, WIPF2 and CASC3 for BRCA, COX6A1 and PRAP1 for CRC, E2F1 and AKR1C3 for LUSC, and TSPAN3 and SLC4A11 for OVCA (Fig. 3K).