ERBB2 and colorectal carcinoma: Key hub genes identified such as ERBB2 [45] in BRCA Mod1, EPCAM [46] in CRC Mod1, TP63 [47] in LUSC Mod1, and MUC16 [48, 49] in OVCA Mod1 that play pivotal roles in malignant cell proliferation, further supported that the first cluster is corresponding to tumorigenesis-related modules (Fig. 3H).