GSTM1 and Decreased total leukocyte count: Laboratory results during bleeding episodes revealed profound cytopenias: thrombocytopenia (median PLT: 11 × 109/L) and anemia (median Hb: 7.1 g/dL) were universal, with frequent leukopenia (median WBC: 1.3 × 109/L) and neutropenia (median ANC: 0.1 × 109/L).