Additionally, PF10 suppressed the proliferation of cancer cell lines, with IC50 values ranging from 2.0 to 2.5 μg/mL, and induced apoptosis, as evidenced by Poly (ADP-ribose) polymerase (PARP) cleavage, activation of caspase 3 and caspase 9 and Bax protein accumulation. Here, CASP9 is linked to cancer.