TNF and neoplasm: Collectively, these antioxidant, hepatoprotective, and DNA-protective properties of Carvacrol [68] contribute to its observed anticancer efficacy in DMBA-induced breast carcinogenesis.Taken together, our results demonstrate that Carvacrol exerts a multi-targeted anticancer effect by activating both intrinsic (p53/p73, BCL2 down-regulation, cytochrome c release) and extrinsic (TRAIL, FADD, DR2, TNF-α, caspase-8) apoptotic pathways, while simultaneously mitigating oxidative stress and restoring liver and kidney biomarkers.