Carvacrol receiving rat’s up-regulated P53 concentrations markedly that reached their peak in the injected (## P ≤ 0.01 vs. tumor and **P ≤ 0.01 vs. normal) as well as oral and mixed groups (#P ≤ 0.05 vs. tumor and *P ≤ 0.05 vs. normal) when compared to tumor-bearing rats (Fig. 3B). Here, TP53 is linked to neoplasm.