Lastly, HMG-CoA reductase inhibitors (statins), commonly prescribed for hyperlipidemia, have been shown to induce ferroptosis through multiple mechanisms including indirect inhibition of the PD-L1 pathway via action on interleukin-enhancing binding factor 3 (ILF3) and downregulation of antioxidant defenses such as GSH, GPX4, and SLC7A11 [52,53]. The gene discussed is ILF3; the disease is hyperlipidemia.