NFE2L2 and non-small cell lung carcinoma: Conversely, the transcription factor NFE2L2 (NRF2), activated in many non-small-cell lung cancers (NSCLCs) contributes to ferroptotic resistance by upregulating ferritin, an iron sequestering protein which depletes the LIP, and other antioxidant genes including GPX4 and SLC7A11, a cystine/glutamate membrane transporter required for GSH production [30].