Accordingly, IHC analysis demonstrated that the levels of p-AKT1 and p-GSK3β were higher in tumor tissues from mice in the LRRC1-OV group than those in the EV group (p < 0.01, Figure S3); in contrast, those in LRRC1-knockdown cells were obviously suppressed (p < 0.01), compared with the corresponding control cells (Figure 5C,D). Here, GSK3B is linked to neoplasm.