Conversely, several studies have shown that cathepsin deficiency (CtsB, CtsL, CtsS) does not affect TNF, IFN-β, IL-6, or IL-10 secretion by BMDCs in response to LPS, CpG, live or killed L. major promastigotes, or ectromelia virus (ECTV) [65,66,67]. This evidence concerns the gene CTSS and hyperinsulinemic hypoglycemia, familial, 4.