In an animal model, PES was observed to inhibit HSP70 (HSPA1A/B)–client interaction, thereby suppressing tumor cell proliferation and migration, inducing apoptosis and cell cycle arrest, inhibiting tumor growth, downregulating the phosphorylation of AKT and ERK, dysregulating autophagy, and impairing lysosomal function. Here, HSPA1A is linked to neoplasm.