The association between HSP90 and AKT and hypoxia-inducible factor 1-alpha (HIF-1α) contributes to the functional stabilization of PI3K/AKT signaling vital for glycolysis-dependent tumor cell survival and participates in the control of metabolic reprograming [2] that enables tumor cells to sustain elevated proliferation rates and endure stressors. The gene discussed is AKT1; the disease is neoplasm.