CDKN1B and atherosclerosis: LincRNA-p21, a known tumor suppressor, alleviates atherosclerosis by sequestering miR-221: Zhang et al. showed that lincRNA-p21 expression is downregulated in atherosclerotic plaques, and overexpression of lincRNA-p21 increases miR-221 targets (e.g., CDKN1B/p27) and reduces macrophage foam cell formation [12].