It cooperates with the RNA-binding protein PTB to repress the translation of AdipoR1 by binding its 3′UTR; in genetic and dietary obesity models, upregulated miR-221 (and PTB) reduces AdipoR1 protein levels, impairing adiponectin signaling and insulin sensitivity [7]. Here, ADIPOR1 is linked to obesity due to melanocortin 4 receptor deficiency.