PARK7 and Parkinson disease: In neurological disorders, miR-221 emerged as a neuroprotective factor in Parkinson’s disease (PD): the PD-linked protein DJ-1 upregulates miR-221 via the MAPK/ERK pathway, which then represses pro-apoptotic proteins (BCL2 like 11(BIM), BMF) to protect dopaminergic neurons from oxidative stress [17].