Oncosomes (100–400 nm) are also some tumor-derived EVs that contain cancer-cell-derived bioactive molecules, such as growth factors (e.g., TGF-β1, VEGF, etc.), non-coding RNAs, oncogenes that enhance tumor progression, migration, TME modification, ECM remodeling, modulation of Treg and cytotoxic T-cells function, neoangiogenesis, and metastasis, as well as drug resistance [39]. This evidence concerns the gene VEGFA and cancer.