Gene set enrichment analysis revealed that ESCs from all EM lesion types showed altered expression of genes involved in cell division/proliferation (e.g., CDC20, PLK1, KIF18B, RRM2), and cell migration/adhesion (e.g., EFNB2, ITGB4, ICAM1; Figure 3B,C), which matches our cell culture observations. The gene discussed is RRM2; the disease is erythema multiforme.