MYOM2 and hypercalcemia disease: MGUS is diagnosed based on the presence of a serum monoclonal protein (M protein) at a concentration < 3 g/dL, a bone marrow with <10 percent monoclonal plasma cells, absence of end-organ damage, such as lytic bone lesions, anemia, hypercalcemia, etc., and lack of B-cell lymphoma or other M-protein-producing disease [11].