In the more malignant MDA-MB-231 human breast cancer cells (compared with MCF-7), loss of DNA methylation and altered expression of DNMT1, as well as methyl-binding proteins methyl-CpG binding protein 2 (MeCP2) and methyl-CpG binding domain protein 2 (MBD2), were observed relative to the non-tumorigenic MCF-10-2A epithelial breast cells [69]. Here, MBD2 is linked to breast cancer.