H2AX and non-small cell lung carcinoma: Similarly, carbon-ion radiotherapy elevates METTL3 levels in non-small-cell lung cancer (NSCLC), and METTL3 knockdown impairs the proliferation, migration, and invasion of NSCLC cells, both in vivo and in vitro, by inhibiting H2A histone family member X (H2AX) mRNA degradation, which leads to enhanced DNA damage repair and increased cell survival [45].