MACROH2A1 and neoplasm: Among the genes significantly associated with clinical response and altered methylation were: H2A histone family, member Y (H2AFY), involved in the epigenetic response [76]; cathepsin A (CTSA), responsible for degradation intra- and extracellular substrates [77]; leukotriene C4 synthase (LTC4S), participating in the synthesis of proinflammatory lipid mediator [78]; interleukin 5 receptor subunit alpha (IL5RA), involved in immune response regulation [79]; and RB transcriptional corepressor 1 (RB1), a key cell cycle/tumor suppressor [80].