In non-small cell lung cancer (NSCLC) clinical samples, suppressed expression of KDM5B and enhanced radioresistance of NSCLC through the downregulation of phosphatase and TENsin homolog (PTEN) expression, a crucial tumor suppressor that inhibits cell growth, proliferation, and survival [129], was reported to be caused by KDM5B [98]. Here, PTEN is linked to neoplasm.