CLN5 and myopia: Our previous studies pointed to important roles for RPE-derived BMPs as critical signaling molecules in eye growth regulation in the chick model [18,19,20,21,22,23,24], with more supporting evidence implicating BMP2 emerging from our recent study involving contact lens-induced myopia in the guinea pig model, in which both Bmp2 and Id3 gene expression were found to be downregulated in RPE [19].