Building on this observation, subsequent work treated TBI mice with the caspase-1 inhibitor Ac-YVAD-cmk and confirmed that pharmacological blockade of caspase-1 attenuates pyroptosis and promotes cognitive recovery, underscoring the therapeutic potential of targeting caspase-1 for the treatment of post-TBI cognitive impairment [72]. This evidence concerns the gene CASP1 and Cognitive impairment.