This intersection of metabolism and survival is further exemplified in hematopoietic malignancies, where Cdk5-dependent phosphorylation of the BH3-only protein NOXA at Ser13 simultaneously restrains its pro-apoptotic function while shifting glucose flux toward the pentose phosphate pathway, a key anabolic and antioxidant pathway essential for cancer cell survival [114]. Here, CDK5 is linked to cancer.