ACSS2 and glioblastoma: Similarly, in glioblastoma, a key O-GlcNAc–Cdk5– acyl-CoA synthetase short-chain family member 2 (ACSS2) signaling pathway links acetate utilization to the lipid synthesis critical for tumor growth: O-GlcNAc transferase (OGT)-mediated O-GlcNAcylation enhances Cdk5 activity, which in turn phosphorylates ACSS2 at Ser267 to stabilize the enzyme and drive acetyl-CoA production [124].