For example, Cdk5-mediated phosphorylation of nuclear distribution element 1 (Nde1), a paralog of Ndel1, is essential for proper neuronal lamination, and a schizophrenia-associated mutation in Nde1 has been shown to impair this specific phosphorylation, providing a direct molecular link between Cdk5 signaling and neurodevelopmental disorders [45]. This evidence concerns the gene NDE1 and neurodevelopmental disorder.