CHMP5 and Cognitive impairment: Underscoring the central role of IL-1β in cognitive impairment is a recent study using a mouse model of acute SARS-CoV-2 infection, which showed not only an infiltration of activated monocytes with microglial activation and an increase in brain IL-1β that decreased neurogenesis and promoted cognitive impairment, but also that vaccination with a low dose of SARS-CoV-2 spike protein prevented IL-1β expression and blocked the subsequent decreased neurogenesis and neurocognitive deficits [75].