In vitro, Mo et al. [108] established a COPD cell model by treating the human lung fibroblast line MRC-5 with lipopolysaccharide and demonstrated that lncRNA GAS5 overexpression facilitates pyroptosis in pulmonary fibroblasts through activation of the miR-223-3p/NLRP3 axis. The gene discussed is NLRP3; the disease is chronic obstructive pulmonary disease.