Importantly, recent proteomic studies suggest that alterations in these proteins are associated with olfactory dysfunction, including idiopathic and age-related smell loss—where LCN15, fibronectin, and HSP70 show reduced expression—and various pathological conditions, including chronic rhinosinusitis, in which LCN2 and BPIF proteins are notably dysregulated. The gene discussed is LCN2; the disease is chronic rhinosinusitis.