MKI67 and neoplasm: Bioinformatics data revealed a significant correlation between FSCN1 expression and a proliferation signature score comprising 512 genes, including Ki-67 (MKI67), widely recognized as a global proliferation marker linked to rapid tumor growth and poor clinical outcomes as it is absent in quiescent cells (G0 phase) but present throughout the active phases of the cell cycle (G1, S, G2, and M) [18].