In esophageal squamous cell carcinoma (ESCC), Xie et al. demonstrated through gain- and loss-of-function approaches that fascin regulates cell proliferation and invasiveness via the TGF-β pathway, which is also implicated in promoting epithelial-to-mesenchymal transition (EMT) in BC [7]. The gene discussed is TGFB1; the disease is esophageal squamous cell carcinoma.