Huang et al. identified SKP2 as a direct transcriptional target of STAT3 and IL-6 activation in human cervical carcinoma cells [35], whereas Snyder et al. showed that IL-6 and TNF-α regulate STAT3 and NF-κB binding to the promoter region of fascin and induce its expression in BC cells [36]. This evidence concerns the gene FSCN1 and breast cancer.