YTHDF2 promotes the progression of gastric cancer,23 oral squamous cell carcinoma,24 hepatocellular carcinoma,25 prostate cancer,26 breast cancer27 and glioblastoma,28 but suppresses the development of colorectal cancer,29 osteosarcoma30 and melanoma.31 The gene discussed is YTHDF2; the disease is colorectal cancer.