TERT and Cachexia: Both pathological states (oxidative stress and cachexia) have been associated with disrupted circadian regulation.54,55 Therefore, we first tested the effect of Tert deletion on the function of the central clock in the SCN using the parameters of the output rhythm in locomotor activity in animals exposed to DD (to detect the endogenous period) and 6-hour phase shifts in LD12:12 (to detect the phase-shifting ability).