Conjoint analysis revealed that genes involved in glycolysis (HK, pfkA, PFK, ALDO, gapN (NADP+)) and acetyl-CoA biosynthesis (DLAT, aceF, pdhC, aceE, paaF, GCDH, gcdH, fadB) were upregulated in the CRC groups. The gene discussed is PFKM; the disease is colorectal carcinoma.