SREBF1 and colorectal carcinoma: Metabolites enriched in patients with CRC, such as cholesterol, were positively correlated with potential pathogenic bacteria such as Escherichia and Proteobacteria. Furthermore, genes involved in methane production (K00200-fwdA, fmdA, K13942-hmd, K00577-mtrA) exhibited a significant positive correlation with Methanobrevibacter.