For example, CAM (Crassulacean acid metabolism) (genes: ppc, mqo, pps), Methanogenesis (genes: fwdA, ftr, hmd, mtbA, mtrA), Coenzyme M biosynthesis (genes: mcrA, comA, comB), Methanofuran biosynthesis (genes: mfnA, mfnD, mfnF), Dissimilatory nitrate reduction (genes: narG, nirB, narK), Assimilatory sulfate reduction (metabolite: Sulfurous acid, genes: asrA, cysJ), Glutathione biosynthesis (gshA, gshB) were elevated in CRC groups (Figure 1B). Here, CLMB is linked to colorectal carcinoma.