CD274 and neoplasm: It is endowed also with immunosuppressive effects, by promoting differentiation and tumor infiltration of MDSCs (184), facilitating M2 polarization (185) and upregulation of IL-1β and PD-L1 (14) in macrophages, inhibiting maturation and activity of DCs (186), and restraining effector functions of NK (187, 188) and T cells (189, 190).