•Serum anti-MAA (IgA, IgG, IgM) antibody positivity (≥95th or 98th percentile in controls) observed in 0.6% to 14.8% of RA participants•Meta-analysis estimated anti-MAA IgG positivity among RA to be 38.5% [95% CI: 20.4%-60.3%]. The gene discussed is CD40LG; the disease is rheumatoid arthritis.