•Increased serum Abs to MAA-modified collagen (IgM), fibrinogen (IgA), and vimentin (IgA/IgG) associated with prevalent RA-ILD•Highest quartile of serum anti-MAA (IgA/IgM) Ab to albumin is associated with two-fold risk of incident RA-ILD. The gene discussed is ALB; the disease is rheumatoid arthritis.