•Incident RA-ILD is associated with IgA and IgM Anti-MAA-albumin (aHR=1.98-2.13, p<0.05) (51).•Prevalent RA-ILD is associated with anti-MAA-collagen (IgM, aOR=1.28, p=0.03), fibrinogen (IgA, aOR=1.48, p=0.003), and vimentin (IgA/IgG, aOR=1.48-1.78, p <0.003) (41).•Predictive modeling incorporating peripheral biomarkers (including expanded anti-MAA antibody profiling) significantly outperformed clinical risk factor alone in identifying RA-ILD (AUC 0.739 vs. 0.630) (51). The gene discussed is CD40LG; the disease is interstitial lung disease.