NR1H4 and colitis: (83) reported that the deletion of the FXR gene exacerbated colitis in mice, whereas treatment with 6-ethylchenodeoxycholic acid (6E-CDCA) alleviated colitis severity and reduced the activation of immune cells and the expression of proinflammatory cytokines in wild-type (WT) mice, but similar effects were not detected in FXR-deficient (FXR-/-) mice.