NR1I2 and metabolic dysfunction-associated steatotic liver disease: In NAFLD models, the PXR-FXR-CAR tri-receptor network jointly determines the degree of lipid accumulation in hepatocytes by regulating the expression of lipid synthesis enzymes and transporters, with PXR activation partially reversing the lipid metabolic disorder caused by FXR deficiency (58, 59), highlighting its pivotal nodal role in disease networks.