HMGB1 and multiple sclerosis: For example, DAMPs like HMGB1 and cell free DNA (cfDNA) from neutrophil NETosis have been correlated with sepsis severity (15–17) Furthermore, DAMPs can play a role in initiating autoimmune conditions with multiple sclerosis studies highlighting the role that high-mobility group box 1 (HMGB1) and heat shock protein 70 (HSP70) play in autoimmune encephalomyelitis (18–20).