Beyond its direct regulation of cell proliferation and apoptosis, IRF8 inhibits the activation of the IL6-JAK-STAT3 pathway in lung adenocarcinoma cells, reducing the differentiation of MDSCs and significantly weakening the immunosuppressive microenvironment, thereby indirectly suppressing the progression of lung adenocarcinoma (61). The gene discussed is STAT3; the disease is lung adenocarcinoma.