CXCR4 and neoplasm: In a mouse model of pancreatic cancer, the injection of CAR-T cells specific to pancreatic ductal adenocarcinoma-associated antigens, which coexpress CXCR4, initiated an antitumor immune response, enhanced the migration of CAR-T cells, diminished the recruitment of MDSCs, and increased the presence of CD8+T cells within tumor tissues (158).