TGFB1 and diabetes mellitus: In contrast, EPA-E inhibited the increase in Erk1/2 phosphorylation and ameliorated tethered dilatation and albuminuria by inhibiting EndMT and TGF-β-mediated renal fibrotic signaling, as well as inhibiting diabetes-induced upregulation of MCP-1 and TGF-β expression and decreasing MDA (Yasuza et al., 2021).