After the administration of isoglycyrrhizin, IL-6 and ICAM inflammatory cytokines were significantly downregulated, and the expression of p-STAT3 and p-JAK2 was significantly upregulated in DN kidney tissues (p < 0.05), accompanied by a nephroprotective effect, which confirms that isoglycyrrhizin ISO can protect the kidneys of rats in the acute DKD model by down-regulating the signaling pathway of JAK2/STAT3 (Sun et al., 2021). The gene discussed is IL6; the disease is diabetic kidney disease.