Curcumin ameliorated hepatic steatosis and insulin resistance by downregulating the hepatic c-Jun N-terminal kinase 2 (JNK2)/Fork head box protein O1(FOXO1)/B-cell lymphoma 6 (Bcl6) axis and altering the composition and structure of the intestinal flora (Yang et al., 2025). Here, FOXO1 is linked to Insulin resistance.