Body weight gain, lipid levels in serum and liver ↓; amelliorated hepatic steatosis and hepatic-lipogenesis-related genes (SREBP-1c, FAS, ACC1, and SCD-1) expression ↑; Lipolysis genes (SRB1 and HL) and lipid oxidation genes (PPARα and CPT-1) in mice fed a high-fat diet ↑. Here, SREBF1 is linked to fatty liver disease.