Mutations in AML with mutations in nine myelodysplasia-related (AML-MR) genes (ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1, or ZRSR2) are designated as high-risk, independent of other cytogenetic abnormalities. The gene discussed is EZH2; the disease is acute myeloid leukemia.