Mutations in AML with mutations in nine myelodysplasia-related (AML-MR) genes (ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1, or ZRSR2) are designated as high-risk, independent of other cytogenetic abnormalities. This evidence concerns the gene ZRSR2 and acute myeloid leukemia.